Cognitive Decline / Alzheimer’s · Lion’s Mane (+ Reishi support)
Cognitive Decline / Alzheimer’s · Lion’s Mane (+ Reishi support)
Lion’s Mane for Brain Health: What Studies Suggest About Memory & Neuroprotection
Brain fog, memory lapses, and healthy aging are hot topics—for good reason. Lion’s Mane (Hericium erinaceus) has caught attention for its potential to support nerve growth factor (NGF) and neuroplasticity. Meanwhile, Reishi’s antioxidant and anti-apoptotic properties may offer a complementary, protective backdrop.
What the science says (plain English)
- NGF & neurite outgrowth: Compounds called erinacines and hericenones in Lion’s Mane support neurite growth and NGF signaling in lab and animal studies.
- Early human signals: Small, controlled studies report improvements on cognitive measures in mild impairment; more large-scale trials are needed.
- Reishi’s supportive role: Triterpenes and antioxidants may reduce oxidative stress and apoptosis—mechanisms relevant to neurodegenerative pathways.
How might it work?
- Neurotrophic support: Lion’s Mane → NGF pathways (growth, repair, plasticity).
- Inflammation & oxidation: Both species show anti-inflammatory/antioxidant effects in preclinical work.
Key takeaways
- Lion’s Mane shows encouraging early clinical results for cognition, with stronger evidence in preclinical studies.
- Reishi may offer a protective antioxidant environment that complements Lion’s Mane.
- Product quality and extract standardization vary; human data remain limited.
TCM perspective
Hóu Tóu Gū (Lion’s Mane) is used to support the Spleen and Stomach (gut–brain axis) and nourish the five Yin organs. Ling Zhi (Reishi) calms the Shen—together reflecting a whole-system approach to clarity and resilience.
Suggested “research dose” context
Literature often references ~3–5 g/day (Lion’s Mane) and ~1–3 g/day (Reishi) in summary contexts—not medical advice. Personalize with a qualified professional.
References (selected)
- Li I-C, et al. Front Aging Neurosci. 2020;12:155.
- Szućko-Kociuba I, et al. Int J Mol Sci. 2023;24(21):15960.
- Tripodi F, et al. Nutrients. 2022;14(20):4368.
- Tzeng T-T, et al. J Biomed Sci. 2016;23:49.
Educational content only. Not medical advice. Consult a qualified professional, especially if pregnant, nursing, pre-op, or taking medications.